Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind, and placebo-controlled clinical trial

Abstract Objective Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interaction and by restricted and repetitive patterns of behavior. Some studies have shown that substances derived from Cannabis sativa improve the quality of life of children with ASD without causing serious adverse effects, thus providing an alternative therapeutic option. The objective of this study was to evaluate the efficacy and safety of a cannabis extract rich in cannabidiol (CBD) in children with ASD. Methods In this randomized, double-blind, placebo-controlled clinical trial, 60 children, aged from 5 to 11 years, were selected and divided into two groups: the treatment group, which received the CBD-rich cannabis extract, and the control group, which received the placebo. They both used their respective products for a period of 12 weeks. Statistical analysis was done by two-factor mixed analysis of variance (two-way ANOVA). Results Significant results were found for social interaction (F1,116 = 14.13, p = 0.0002), anxiety (F1,116 = 5.99, p = 0.016), psychomotor agitation (F1,116 = 9.22, p = 0.003), number of meals a day (F1,116 = 4.11, p = 0.04), and concentration (F1,48 = 6.75, p = 0.01), the last of which was only significant in mild ASD cases. Regarding safety, it was found that only three children in the treatment group (9.7%) had adverse effects, namely dizziness, insomnia, colic, and weight gain. Conclusion CBD-rich cannabis extract was found to improve one of the diagnostic criteria for ASD (social interaction), as well as features that often co-exist with ASD, and to have few serious adverse effects.

Identifying biomarkers for tDCS treatment response in Alzheimer's disease patients: a machine learning approach using resting-state EEG classification.

Background: Transcranial direct current stimulation (tDCS) is a promising treatment for Alzheimer's Disease (AD). However, identifying objective biomarkers that can predict brain stimulation efficacy, remains a challenge. The primary aim of this investigation is to delineate the cerebral regions implicated in AD, taking into account the existing lacuna in comprehension of these regions. In pursuit of this objective, we have employed a supervised machine learning algorithm to prognosticate the neurophysiological outcomes resultant from the confluence of tDCS therapy plus cognitive intervention within both the cohort of responders and non-responders to antecedent tDCS treatment, stratified on the basis of antecedent cognitive outcomes. Methods: The data were obtained through an interventional trial. The study recorded high-resolution electroencephalography (EEG) in 70 AD patients and analyzed spectral power density during a 6 min resting period with eyes open focusing on a fixed point. The cognitive response was assessed using the AD Assessment Scale-Cognitive Subscale. The training process was carried out through a Random Forest classifier, and the dataset was partitioned into K equally-partitioned subsamples. The model was iterated k times using K-1 subsamples as the training bench and the remaining subsample as validation data for testing the model. Results: A clinical discriminating EEG biomarkers (features) was found. The ML model identified four brain regions that best predict the response to tDCS associated with cognitive intervention in AD patients. These regions included the channels: FC1, F8, CP5, Oz, and F7. Conclusion: These findings suggest that resting-state EEG features can provide valuable information on the likelihood of cognitive response to tDCS plus cognitive intervention in AD patients. The identified brain regions may serve as potential biomarkers for predicting treatment response and maybe guide a patient-centered strategy. Clinical Trial Registration: https://classic.clinicaltrials.gov/ct2/show/NCT02772185?term=NCT02772185&draw=2&rank=1, identifier ID: NCT02772185.

Personalidade de insensibilidade e afetividade restrita em crianças vítimas de bullying / Callous-unemotional personality in children bullying victims / Personalidad de la insensibilidad y afectividad restringida en niños víctimas de bullying

A personalidade com insensibilidade e afetividade restrita (Callous-Unemotional personality) é bem investigada nos agressores de bullying, porém pouco se sabe sobre essa característica nas vítimas. O presente estudo objetivou avaliar a personalidade de insensibilidade e afetividade restrita em crianças que vivenciaram situações de bullying. Participaram da pesquisa 60 crianças do 6.º ano escolar divididas em grupos de agressores (n=15), vítimas (n=15), vítimas-agressores (n=15), e grupo controle (n=15). Foram aplicadas escalas de personalidade e de comportamento. Os resultados apontaram que as vítimas demonstraram um nível mais baixo de personalidade com insensibilidade e afetividade restrita se comparado aos outros grupos, apresentando também maior nível de comportamento pró-social. Torna-se, então, necessário investigar se níveis mais baixos deste traço de personalidade estão associados a maior passividade nas vítimas e, consequentemente, a uma maior probabilidade de serem alvo de bullying.

The Callous-Unemotional personality it is well examined among bullying aggressors, however little is known regarding this characteristic in victims. The present study aimed to investigate the insensibility and coldness in children living under bullying circumstances. Sixty children of the 6° school grade took part in the study, divided in groups of aggressors (n=15), victims (n=15), bully-victims (n=15), and a control group (n=15). Personality and behavior assessment scales were applied. Results revealed that victims showed a lower level of Callous-Unemotional personality compared to other groups, and also presented a higher level of pro-social behavior. It turns necessary to investigate if lower levels of those personality traits are associated to a higher passivity in victims and, consequently, to a greater probability of being target of bullying.

La personalidad con insensibilidad y afectividad restringida (Callous-Unemotional Personality) está bien investigada en agresores de bullying, pero poco se sabe sobre este rasgo en las víctimas. El presente estudio tuvo como objetivo evaluar la personalidad de insensibilidad y afectividad restringida en niños que experimentaron situaciones de bullying. Participaran de la investigación 60 niños del 6º año escolar divididos en grupos de agresores (n = 15), víctimas (n = 15), víctimas-agresores (n = 15) y grupo controle (n = 15). Se aplicaron escalas de personalidad y conducta. Los resultados mostraron que las víctimas mostraron un menor nivel de personalidad con insensibilidad y afectividad restringida en comparación con los otros grupos, además de presentar un mayor nivel de conducta prosocial. Entonces se hace necesario investigar si los niveles más bajos de este rasgo de personalidad están asociados con una mayor pasividad en las víctimas y, en consecuencia, a una mayor probabilidad de ser acosado.

Facial Emotion Recognition and Executive Functions in Insomnia Disorder: An Exploratory Study.

BACKGROUND: Clinical and experimental findings suggest that insomnia is associated with changes in emotional processing and impairments in cognitive functioning. In the present study, we investigate the relationship between facial emotion recognition and executive functioning among individuals with insomnia as well as healthy controls. METHOD: A total of 11 individuals (mean age 31.3 ± 9.4) diagnosed with insomnia disorder and 15 control participants (mean age 24.8 ± 4.6) took part in the study. Participants responded to a facial emotion recognition task which presented them with static and dynamic stimuli, and were evaluated with regard to cognition, sleep, and mood. RESULTS: Compared to controls, we found that participants with insomnia performed worse in the recognition of the facial emotion of fear (p = 0.001; η p 2 = 0.549; ß = 0.999) and had lower scores in tests of verbal comprehension and perceptual organization (104.00 vs. 115.00, U = 135.5; p = 0.004; Cohen's, 2013 d = 1.281). We also found a relationship between facial emotion recognition and performance in cognitive tests, such as those related to perceptual organization, cognitive flexibility, and working memory. CONCLUSION: Results suggest that participants with insomnia may present some impairment in executive functions as well as in the recognition of facial emotions with negative valences (fear and sadness).

Tarefa de compatibilidade espacial afetiva como modelo de estudo do comportamento emocional / Affective spatial compatibility task as a model for the study of emotional behavior / Tarea de compatibilidad espacial afectiva como modelo para el estudio del comportamiento emocional

Além dos aspectos emocionais, o comportamento humano pode ser afetado por outros fatores, tal como a localização espacial dos estímulos, que favorecem a ocorrência de respostas motoras mais rápidas para o mesmo lado de sua apresentação em uma tarefa clássica de compatibilidade estímulo-resposta. O presente artigo consiste em uma revisão narrativa de estudos que utilizaram a Tarefa de Compatibilidade Espacial Afetiva (TCEA) para avaliar a influência da valência afetiva do estímulo sobre os padrões de compatibilidade espacial. De modo geral, os estudos analisados indicam que figuras, imagens e palavras com valência emocional são capazes de influenciar o comportamento do voluntário. Portanto, a TCEA é uma ferramenta com potencial aplicação ao estudo da interação entre emoção e cognição na avaliação neuropsicológica.

Besides emotional aspects, human behavior can be affected by other factors, such as the spatial location of stimuli, which tend to facilitate the occurrence of faster motor responses to stimulus at the same side in a classic stimulus-response compatibility task. This article consists of a narrative review of studies that used the Affective Spatial Compatibility Task (TCEA) to assess the influence of the stimulus' affective valence on spatial compatibility patterns. In general, studies analyzed indicate that figures, images and words with emotional valence are capable of influencing the subject's behavior. Thus, we conclude that TCEA is a tool with potential application to the study of the interaction between emotion and cognition in the neuropsychological evaluation.

Además de los aspectos emocionales, el comportamiento humano puede verse afectado por otros factores, como la ubicación espacial de los estímulos, que favorecen la aparición de respuestas motoras más rápidas al estímulo en el mismo lado en una tarea de compatibilidad estímulo-respuesta. Este artículo consiste en una revisión narrativa de estudios que utilizaron la Tarea compatibilidad espacial afectiva (TCEA) para evaluar la influencia de la valencia afectiva del estímulo en los patrones de compatibilidad espacial. En general, los estudios analizados indican que las figuras, imágenes y palabras con valencia emocional son capaces de influir en el comportamiento del sujeto. TCEA es una herramienta con potencial aplicación para el estudio de la interacción entre emoción y cognición en la evaluación neuropsicológica.

Neurostimulation Combined With Cognitive Intervention in Alzheimer's Disease (NeuroAD): Study Protocol of Double-Blind, Randomized, Factorial Clinical Trial.

Despite advances in the treatment of Alzheimer's disease (AD), there is currently no prospect of a cure, and evidence shows that multifactorial interventions can benefit patients. A promising therapeutic alternative is the use of transcranial direct current stimulation (tDCS) simultaneously with cognitive intervention. The combination of these non-pharmacological techniques is apparently a safe and accessible approach. This study protocol aims to compare the efficacy of tDCS and cognitive intervention in a double-blind, randomized and factorial clinical trial. One hundred participants diagnosed with mild-stage AD will be randomized to receive both tDCS and cognitive intervention, tDCS, cognitive intervention, or placebo. The treatment will last 8 weeks, with a 12-month follow-up. The primary outcome will be the improvement of global cognitive functions, evaluated by the AD Assessment Scale, cognitive subscale (ADAS-Cog). The secondary outcomes will include measures of functional, affective, and behavioral components, as well as a neurophysiological marker (Brain-derived neurotrophic factor, BDNF). This study will enable us to assess, both in the short and long term, whether tDCS is more effective than the placebo and to examine the effects of combined therapy (tDCS and cognitive intervention) and isolated treatments (tDCS vs. cognitive intervention) on patients with AD. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT02772185-May 5, 2016.

O efeito Simon induzido pela direção do olhar em faces de dor e alegria / The Simon effect triggered by the gaze direction in painful and happy faces / El efecto Simon inducido por la dirección de la mirada en rostros de dolor y alegría

Embora irrelevante para a tarefa, a direção do olhar pode influenciar o tempo de reação em uma tarefa de Simon, gerando automaticamente um código espacial. Expressões faciais influenciam as respostas dos observadores, ativando tendências comportamentais de aproximação ou afastamento. No presente estudo, investigamos se a facilitação da resposta desencadeada pela direção do olhar seria reduzida na avaliação de expressões faciais de dor em comparação com alegria. Foi também analisado o efeito de sequência da apresentação das expressões, onde a facilitação ou inibição provocada por uma expressão emocional afeta a resposta na prova subsequente. Os resultados mostram que as faces dolorosas causam inibição da resposta na prova atual e posterior, indicando empatia emocional pela dor. O tipo da expressão facial não influenciou a facilitação da resposta promovida pela direção do olhar. Esta metodologia é apresentada como uma estratégia para investigar a empatia emocional, especialmente nos distúrbios relacionados à redução da empatia.

Although irrelevant to the task, gaze direction can influence reaction time responses in a Simon task insofar as it automatically generates a spatial code. Facial expressions also influence observers' responses and they can activate approach or avoidance behavioral tendencies. In the present study, we investigated whether the facilitation of the response triggered by gaze direction would be reduced for the evaluation of facial expressions of pain as compared to happiness. We also analyzed the effect of sequence presentation of the facial expressions, in which the facilitation or inhibition caused by an emotional expression affects the response in a subsequent trial. Results show that painful faces cause a response inhibition in the present and subsequent trials, indicating an emotional empathy for pain. The type of the facial expression (happiness or pain) did not influenced the facilitation of the response promoted by gaze direction. This methodology is presented as a new strategy to investigate emotional empathy, especially in disorders related to the reduction of the empathy.

Aunque irrelevante para la tarea, la dirección de la mirada puede influir en las respuestas del tiempo de reacción en una tarea de Simon en la medida en que genera automáticamente un código espacial. Las expresiones faciales también influyen en las respuestas de los observadores y pueden activar tendencias de comportamiento de acercamiento o evitación. En el presente estudio, se investigó si la facilitación de la respuesta provocada por la dirección de la mirada se reduciría para la evaluación de expresiones faciales del dolor en comparación con felicidad. También analizamos el efecto de la secuencia de la presentación de las expresiones faciales, en que la facilitación o inhibición causada por una expresión emocional afecta la respuesta en el ensayo posterior. Los resultados muestran que las caras dolorosas causan una inhibición de la respuesta en los ensayos presentes y posteriores, lo que indica una empatía emocional por el dolor. El tipo de expresión facial (felicidad o dolor) no influyó en la facilitación de la respuesta promovida por la dirección de la mirada. Esta metodología se presenta como una nueva estrategia para investigar la empatía emocional, especialmente en los trastornos relacionados con la reducción de la empatía.

Transcranial direct current stimulation over the primary motor vs prefrontal cortex in refractory chronic migraine: A pilot randomized controlled trial.

Although transcranial direct current stimulation (tDCS) represents a therapeutic option for the prophylaxis of chronic migraine, the target area for application of the electrical current to the cortex has not yet been well established. Here we sought to determine whether a treatment protocol involving 12 sessions of 2mA, 20min anodal stimulation of the left primary motor (M1) or dorsolateral prefrontal cortex (DLPFC) could offer clinical benefits in the management of pain from migraine. Thirteen participants were assessed before and after treatment, using the Headache Impact Test-6, Visual Analogue Scale and Medical Outcomes Study 36 - Item Short - Form Health Survey. After treatment, group DLPFC exhibited a better performance compared with groups M1 and sham. On intragroup comparison, groups DLPFC and M1 exhibited a greater reduction in headache impact and pain intensity and a higher quality of life after treatment. No significant change was found in group sham. The participants in group M1 exhibited more adverse effects, especially headache, heartburn, and sleepiness, than did those in the other two groups. Transcranial direct current stimulation is a safe and efficacious technique for treating chronic migraine. However, it should be kept in mind that the site of cortical stimulation might modulate the patient's response to treatment.

Eficácia e limitação da terapia vocal na doença de Parkinson: revisão de literatura / Effectiveness and limitations of vocal therapy in Parkinson's disease: a literature review

RESUMO: O objetivo desta revisão de literatura foi verificar as evidências científicas e restrições dos diferentes tipos de tratamentos para voz na Doença de Parkinson. O levantamento dos artigos foi realizado nas bases de dados PubMed/MEDLINE, SciELO e Lilacs. Utilizou-se como estratégia de busca as combinações com os seguintes descritores: "Parkinson disease and vocal therapy"; "Parkinson disease and speech acoustic"; "Parkinson disease and voice". Os critérios de inclusão foram: idioma em português ou inglês; artigos dos anos 2003-2013; e estudos de intervenção. Adotou-se como critérios de exclusão: os repetidos nas bases de dados; pesquisas com animais. Durante a busca foram localizados 351 artigos, dos quais apenas 18 deles preenchiam os critérios de inclusão adotados no estudo. Os resultados foram apresentados considerando os diferentes tipos de tratamento para a voz na Doença de Parkinson, de acordo com a técnica de intervenção: medicamentoso, cirúrgico e reabilitação, identificando os autores e ano de publicação, características da amostra, o tipo de tratamento, o método utilizado e a conclusão do estudo. Nesta pesquisa observou-se reduzida produção científica no tratamento da voz na doença de Parkinson. A maioria dos artigos abordou as técnicas de tratamento para a voz de alto custo, ou que necessitam de habilitação/certificação no método para a realização da terapia de voz.

ABSTRACT: The aim of this review was to assess the scientific evidences and restrictions of the different kinds of voice treatments in Parkinson's disease. The survey of articles was conducted in the databases PubMed/MEDLINE, SciELO and Lilacs. As a search strategy, combinations with the following descriptors were used: "Parkinson disease and vocal therapy"; "Parkinson disease and speech acoustic"; "Parkinson disease and voice". Inclusion criteria were: Portuguese or English language; articles from 2003-2013; and intervention studies. The following exclusion criteria were adopted: those repeated in the databases; animal research. During the search, 351 articles were found, of which only 18 met the inclusion criteria in the study. The results were presented considering the various types of voice treatment in Parkinson's disease, according to the intervention technique: pharmacological, surgical and rehabilitation, identifying authors and the year of publication, the sample characteristics, the type of treatment, the method used and the conclusion of the study. In this study, it was observed reduced scientific literature for voice treatment in Parkinson's disease. Most articles addressed high-cost treatment techniques for voice, or in need of qualification/certification in the method for carrying out the speech therapy.

Adjuvant transcranial direct current stimulation for treating Alzheimer's disease: A case study / Estimulação transcraniana por corrente continua no tratamento adjuvante da Doença de Alzheimer: estudo de caso

ABSTRACT We report the case of a 73-year-old male patient with Alzheimer's disease who underwent 10-daily transcranial direct current stimulation (tDCS) sessions. tDCS was applied over the left dorsolateral prefrontal cortex as an adjuvant to the traditional treatment that the patient was receiving, which consisted of anticholinergic medication and cognitive training. The data were qualitatively analyzed and are presented in an analytic and structured form. The effects on cognitive performance were evaluated using the Alzheimer's Disease Assessment Scale-cognitive subscale as the primary outcome. Secondary outcomes were assessed with a set of tests consisting of the Neuropsychiatric Inventory, the Blessed Dementia Scale and the Disability Assessment for Dementia. The data obtained revealed that the application of tDCS had a stabilizing effect on overall patient cognitive function and led to improved performance on all the secondary outcome tests. These preliminary results indicate that tDCS is a potential adjuvant therapeutic tool for cognitive rehabilitation in Alzheimer's disease .

RESUMO Nós relatamos o caso de um paciente com 73 anos de idade, diagnosticado com doença de Alzheimer, submetido a 10 sessões diárias de estimulação transcraniana por corrente continua (ETCC). A ETCC foi aplicada sobre o córtex dorsolateral esquerdo como terapêutica adjuvante ao tratamento tradicional que o paciente recebia (medicação anticolinérgica e treino cognitivo). Os dados foram analisados qualitativamente e apresentados em um formato analítico e estruturado. O desempenho foi avaliado através da Alzheimer's Disease Assessment Scale-cognitive subscale, como desfecho primário. Os desfechos secundários incluíram: Neuropsychiatric Inventory, Blessed Dementia Scale e Disability Assessment for Dementia. Os dados obtidos demonstraram que a ETCC teve um efeito estabilizador sobre a função cognitiva geral do paciente e levou ao aumento do desempenho em todos os testes de desfechos secundários. Estes resultados preliminares indicam que a ETCC é uma potencial terapêutica adjuvante para a reabilitação cognitiva na doença de Alzheimer.

Adjuvant transcranial direct current stimulation for treating Alzheimer's disease: A case study.

We report the case of a 73-year-old male patient with Alzheimer's disease who underwent 10-daily transcranial direct current stimulation (tDCS) sessions. tDCS was applied over the left dorsolateral prefrontal cortex as an adjuvant to the traditional treatment that the patient was receiving, which consisted of anticholinergic medication and cognitive training. The data were qualitatively analyzed and are presented in an analytic and structured form. The effects on cognitive performance were evaluated using the Alzheimer's Disease Assessment Scale-cognitive subscale as the primary outcome. Secondary outcomes were assessed with a set of tests consisting of the Neuropsychiatric Inventory, the Blessed Dementia Scale and the Disability Assessment for Dementia. The data obtained revealed that the application of tDCS had a stabilizing effect on overall patient cognitive function and led to improved performance on all the secondary outcome tests. These preliminary results indicate that tDCS is a potential adjuvant therapeutic tool for cognitive rehabilitation in Alzheimer's disease .

Nós relatamos o caso de um paciente com 73 anos de idade, diagnosticado com doença de Alzheimer, submetido a 10 sessões diárias de estimulação transcraniana por corrente continua (ETCC). A ETCC foi aplicada sobre o córtex dorsolateral esquerdo como terapêutica adjuvante ao tratamento tradicional que o paciente recebia (medicação anticolinérgica e treino cognitivo). Os dados foram analisados qualitativamente e apresentados em um formato analítico e estruturado. O desempenho foi avaliado através da Alzheimer's Disease Assessment Scale-cognitive subscale, como desfecho primário. Os desfechos secundários incluíram: Neuropsychiatric Inventory, Blessed Dementia Scale e Disability Assessment for Dementia. Os dados obtidos demonstraram que a ETCC teve um efeito estabilizador sobre a função cognitiva geral do paciente e levou ao aumento do desempenho em todos os testes de desfechos secundários. Estes resultados preliminares indicam que a ETCC é uma potencial terapêutica adjuvante para a reabilitação cognitiva na doença de Alzheimer.

Neurostimulation for cognitive rehabilitation in stroke (NeuroCog): study protocol for a randomized controlled trial.

BACKGROUND: Stroke patients may present severe cognitive impairments, primarily related to executive functions. Transcranial direct current stimulation has shown promising results, with neuromodulatory and neuroplastic effects. This study is a double-blind, sham-controlled clinical trial aiming to compare the long-term effects of stimulation in two different cognitive regions after a stroke. METHODS/DESIGN: Sixty patients who suffer from chronic strokes will be randomized into one of four groups: dorsolateral prefrontal cortex, cingulo-opercular network, motor primary cortex and sham stimulation. Each group will receive transcranial direct current stimulation at an intensity of 2 mA for 20 minutes daily for 10 consecutive days. Patients will be assessed with a Dysexecutive Questionnaire, Semantic Fluency Test, categorical verbal fluency and Go-no go tests, Wechsler Adult Intelligence Scale, Rey Auditory-Verbal Learning Test, Letter Comparison and Pattern Comparison Tasks at baseline and after their tenth stimulation session. Those who achieve clinical improvement with neurostimulation will be invited to receive treatment for 12 months as part of a follow-up study. DISCUSSION: Long-term stimulation could be analyzed in regard to possible adaptive changes on plasticity after structural brain damage and if these changes are different in terms of clinical improvement when applied to two important cognitive centers. TRIALS REGISTRATION: Clinicaltrials.gov, NCT02315807 . 9 December 2014.

Competência emocional e bullying: uma visão da neurociência / Emotional competence and bullying: a view from neuroscience

A competência emocional é extremamente importante no processo de interação entre os pares na idade escolar. A forma como as emoções se apresentam em crianças vítimas e agressoras de bullying ainda é pouco estudada, mas serviria de base para elaboração de programas de prevenção. A partir de uma revisão sistemática nas principais bases de dados, os autores abordam aspectos atuais da relação entre bullying e emoções, conceituando as variáveis, comentando sobre a colaboração da neurociência e apresentando dados de pesquisas da literatura recente sobre o tema.

Recognition of static and dynamic facial expressions: a study review / Reconhecimento de expressões faciais estáticas e dinâmicas: um estudo de revisão

In emotion research, criticism has been directed to the use of static facial expressions, especially concerning its supposedly low ecological validity. In the present work, we performed a review of studies that directly compared the recognition of emotions using static and dynamic facial expressions. Behavioral, neuroimaging, brain damage and facial electromyography studies, published since 1993 were included. Overall, facial motion seems to promote emotional recognition. Neuroimaging and brain damage studies sustain the idea of a dissociation between the systems responsible to process static and dynamic expressions. Electromyography studies indicated that dynamic expressions tend to elicit more intense responses of facial mimic and are related to a higher physiological activation. Those findings support the hypothesis that dynamic facial expressions are ecologically more valid and therefore more appropriate to emotion research.(AU)

Na literatura de estudo das emoções, críticas têm sido dirigidas ao uso de expressões faciais estáticas, principalmente no que se refere a sua suposta baixa validade ecológica. No presente trabalho, foi realizada uma revisão de estudos que compararam diretamente o reconhecimento de emoções usando expressões faciais estáticas e dinâmicas. Foram incluídos estudos comportamentais, de neuroimagem, lesão cerebral e eletromiografia facial, publicados a partir de 1993. De um modo geral, o movimento facial parecer promover o reconhecimento de emoções. Estudos de neuroimagem e lesão cerebral sustentam a ideia de uma dissociação entre os sistemas responsáveis por processar expressões estáticas e dinâmicas. Estudos de eletromiografia indicaram que expressões dinâmicas tendem a eliciar respostas mais intensas de mímica facial e estão relacionadas a uma maior ativação fisiológica. Estes achados sustentam a hipótese de que expressões faciais dinâmicas são ecologicamente mais válidas e, portanto, mais adequados à pesquisa com emoções.(AU)

Recognition of static and dynamic facial expressions: a study review / Reconhecimento de expressões faciais estáticas e dinâmicas: um estudo de revisão

In emotion research, criticism has been directed to the use of static facial expressions, especially concerning its supposedly low ecological validity. In the present work, we performed a review of studies that directly compared the recognition of emotions using static and dynamic facial expressions. Behavioral, neuroimaging, brain damage and facial electromyography studies, published since 1993 were included. Overall, facial motion seems to promote emotional recognition. Neuroimaging and brain damage studies sustain the idea of a dissociation between the systems responsible to process static and dynamic expressions. Electromyography studies indicated that dynamic expressions tend to elicit more intense responses of facial mimic and are related to a higher physiological activation. Those findings support the hypothesis that dynamic facial expressions are ecologically more valid and therefore more appropriate to emotion research.

Na literatura de estudo das emoções, críticas têm sido dirigidas ao uso de expressões faciais estáticas, principalmente no que se refere a sua suposta baixa validade ecológica. No presente trabalho, foi realizada uma revisão de estudos que compararam diretamente o reconhecimento de emoções usando expressões faciais estáticas e dinâmicas. Foram incluídos estudos comportamentais, de neuroimagem, lesão cerebral e eletromiografia facial, publicados a partir de 1993. De um modo geral, o movimento facial parecer promover o reconhecimento de emoções. Estudos de neuroimagem e lesão cerebral sustentam a ideia de uma dissociação entre os sistemas responsáveis por processar expressões estáticas e dinâmicas. Estudos de eletromiografia indicaram que expressões dinâmicas tendem a eliciar respostas mais intensas de mímica facial e estão relacionadas a uma maior ativação fisiológica. Estes achados sustentam a hipótese de que expressões faciais dinâmicas são ecologicamente mais válidas e, portanto, mais adequados à pesquisa com emoções.

Ansiedade social e atribuição de emoções a faces neutras / Social snxiety and attribution of affect to neutral faces

Trabalhos anteriores têm revelado vieses no reconhecimento de emoções e padrões diferenciais de ativação cerebral no transtorno de ansiedade social. No presente estudo, foi investigada a atribuição de emoções a faces neutras em 22 indivíduos com ansiedade social e 20 voluntários controles. Através do método da escolha forçada, participantes atribuíram emoções de alegria, medo, raiva ou tristeza a faces neutras. Verificou-se que homens e mulheres com ansiedade social atribuíram mais frequentemente emoções de raiva e tristeza às faces neutras, respectivamente. A atribuição de raiva por homens pode estar associada à tendência masculina em detectar sinais de hostilidade no ambiente social, enquanto que o aumento na atribuição de tristeza pelas mulheres pode estar associado à facilitação na identificação de emoções negativas. Os resultados sugerem que a ansiedade social afeta diferentemente os sexos e têm implicações importantes sobre o uso da face neutra como condição de base ou controle nas neurociências comportamentais.(AU)

Previous research has revealed facial emotion recognition biases and distinctive patterns of brain activation in social anxiety disorder. We investigated the attribution of emotion to neutral facial displays in 22 subjects with social anxiety and 20 healthy controls. Using a forced choice paradigm, participants labeled neutral faces as happy, fearful, angry or sad. The most frequent emotional labels attributed by males and females to neutral faces were anger and sadness, respectively. These findings are discussed according to the notion that the attribution of anger by men may be associated with the male tendency to detect hostile environmental signs, whereas the increased attribution of sadness by females might be associated with facilitated identification of negative affect. The results suggest that social anxiety disorder differentially affects males and females and has important implications concerning the use of the neutral face as a baseline or control condition in behavioral neuroscience.(AU)

Ansiedade social e atribuição de emoções a faces neutras / Social snxiety and attribution of affect to neutral faces

Trabalhos anteriores têm revelado vieses no reconhecimento de emoções e padrões diferenciais de ativação cerebral no transtorno de ansiedade social. No presente estudo, foi investigada a atribuição de emoções a faces neutras em 22 indivíduos com ansiedade social e 20 voluntários controles. Através do método da escolha forçada, participantes atribuíram emoções de alegria, medo, raiva ou tristeza a faces neutras. Verificou-se que homens e mulheres com ansiedade social atribuíram mais frequentemente emoções de raiva e tristeza às faces neutras, respectivamente. A atribuição de raiva por homens pode estar associada à tendência masculina em detectar sinais de hostilidade no ambiente social, enquanto que o aumento na atribuição de tristeza pelas mulheres pode estar associado à facilitação na identificação de emoções negativas. Os resultados sugerem que a ansiedade social afeta diferentemente os sexos e têm implicações importantes sobre o uso da face neutra como condição de base ou controle nas neurociências comportamentais.

Previous research has revealed facial emotion recognition biases and distinctive patterns of brain activation in social anxiety disorder. We investigated the attribution of emotion to neutral facial displays in 22 subjects with social anxiety and 20 healthy controls. Using a forced choice paradigm, participants labeled neutral faces as happy, fearful, angry or sad. The most frequent emotional labels attributed by males and females to neutral faces were anger and sadness, respectively. These findings are discussed according to the notion that the attribution of anger by men may be associated with the male tendency to detect hostile environmental signs, whereas the increased attribution of sadness by females might be associated with facilitated identification of negative affect. The results suggest that social anxiety disorder differentially affects males and females and has important implications concerning the use of the neutral face as a baseline or control condition in behavioral neuroscience.

The role of vertical disparities in the oblique effect

A great deal of studies using different visual tasks (e.g., Vernier acuity tasks, tilt illusion, crowding, etc) have revealed that our perception is strongly influenced by the orientation of the stimulus. Most studies have investigated visual acuity in two-dimensional visual spaces (2D) but little is known about the effect of line orientation in depth perception (3D). In one experiment, Vernier Acuity (VA) in frontoparallel (2D) and medial (3D) planes was investigated. We used a virtual reality setup inducing inter-ocular disparities to simulate a 3D visual space, and a common computer screen to present stimuli in the frontal plane. In the experiment, by using the method of constant stimuli, the observer compared VA in the 2D and 3D visual spaces as a function of the stimulus orientation. Results showed that only judgments in the 3D condition were affected by the well-known 'oblique effect', and some impairment in stereoacuity (lines in depth plane) in comparison to 2D acuity (lines in frontal plane) was observed. We attributed the cause for such deterioration in stereoacuity to changes in vertical disparities.(AU)

The role of vertical disparities in the oblique effect

A great deal of studies using different visual tasks (e.g., Vernier acuity tasks, tilt illusion, crowding, etc) have revealed that our perception is strongly influenced by the orientation of the stimulus. Most studies have investigated visual acuity in two-dimensional visual spaces (2D) but little is known about the effect of line orientation in depth perception (3D). In one experiment, Vernier Acuity (VA) in frontoparallel (2D) and medial (3D) planes was investigated. We used a virtual reality setup inducing inter-ocular disparities to simulate a 3D visual space, and a common computer screen to present stimuli in the frontal plane. In the experiment, by using the method of constant stimuli, the observer compared VA in the 2D and 3D visual spaces as a function of the stimulus orientation. Results showed that only judgments in the 3D condition were affected by the well-known 'oblique effect', and some impairment in stereoacuity (lines in depth plane) in comparison to 2D acuity (lines in frontal plane) was observed. We attributed the cause for such deterioration in stereoacuity to changes in vertical disparities.

Produção científica na Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto - USP: aplicação do índice de Hirsch / Scientific bibliographic productivity at FFCLRP-USP (undergraduate courses and graduate programs): an application of the h-index

O objetivo do presente trabalho foi analisar/quantificar a produtividade cientifica dos docentes pertencentes à Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo (FFCLRP-USP) vinculados aos oito cursos de graduação e seis programas de pós-graduação. Métodos: Os índices analisados para cada professor foram: 1) número total de artigos (na plataforma Lattes), 2) número de artigos indexados pela Thomson ISI Web ofScience, e 3) o índice-h. Aplicamos os testes ANOVA, Kruskall-Wallis e o Post Hoc (Bonferrroni) para identificar possíveis diferenças entre os cursos de graduação e os programas de pósgraduação.

In this work, an analysis of scientific bibliographic productivity was made using the Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo (FFCLRPUSP) as example. It is a special Institution in the Brazilian University system which encompasses four important areas of knowledge (fields of concentration) in natural, biological, humanities, and social areas. It is composed by four departments which offer altogether eight undergraduate courses:1) Psychology, 2) Pedagogy, 3) Chemistry, 4) Biology, 5) Medical Physics, 6) Biomedical Informatics,7) Sciences of Information and Documentation and 8) Mathematics Applied to Business and sixgraduate programs leading to M.S. and Ph.D. degrees. Moreover, when analyzing the different courses of FFCLRP, they represent typical academic organization in Brazil and Latin America and could be taken as a model for analyzing other Brazilian research institutions.